Pharmaceutical manufacturers of Methotrexate

Founded in 1956, Zhejiang Hisun Pharmaceutical Co., Ltd. is a comprehensive pharmaceutical enterprise featuring whole chain, multi-regional integration of research, production and marketing as well as development of drug substances and preparations. In 2000, an A-share was issued in order to enter the stock market as a state-owned listed company. As of 2021, Hisun Pharmaceutical is now one of the largest producers of antibiotics and anti-tumor drugs in China and has been listed in the Top 500 Chinese manufacturing enterprises and the Top 100 Chinese pharmaceutical enterprises multiple times. In 2020 Hisun Pharmaceuticals received special recognition from the Joint Prevention and Control Team from the State Council of the People’s Republic of China for their extraordinary efforts in the fight against the epidemic, and Hisun Pharmaceutical was awarded with the “Anti COVID-19 Advanced Collective in Ministry of Industry and Information Technology".

Fermion specializes in the development, production, and promotion of active pharmaceutical ingredients (APIs) for the global generic market and exclusive contracts for new chemical entities (NCEs). It is a wholly owned subsidiary of Orion Corporation, with its headquarters in Espoo, Finland. Partnered with Orion, Fermion offers comprehensive services encompassing APIs and Formulations, including a portfolio of over 30 generic APIs and more than 10 NCEs. The manufacturing and R&D facilities are all based in Finland, with an emphasis on expanding capabilities in the production of high-potency APIs (HPAPIs). Additionally, Fermion and Orion provide a range of drug product CMO services, such as hormonal and non-hormonal semi-solids, liquids, cytotoxic oral solids, packaging, small volume parenterals, and non-cytotoxic oral solids. Orion operates three manufacturing sites and one packaging center for drug products.

Intas is a leading, vertically integrated global pharmaceutical formulation development, manufacturing, and marketing company. Intas is committed to challenging the unmet medical and societal needs through a comprehensive pharmaceutical value chain spanning across the world. Intas has set up a network of subsidiaries, under the umbrella name of Accord Healthcare to operate in global markets. Over the years, Intas has grown both organically and via acquisition, expanding its product portfolio and operations year on year. It is currently present in more than 85 countries worldwide with robust sales, marketing and distribution infrastructure in markets like North America, Europe, Central & Latin America, Asia-Pacific as well as CIS and MENA countries. Intas’ remarkable success in North America and European operations have helped us emerge as a global brand in the world’s largest pharmaceutical markets.

Benzo Chem Industries Pvt. Limited and Gitanjali Chemicals Pvt. Limited are wholly owned companies of Mohatta Group. It all began three decades ago in 1982; Gitanjali Chemicals Pvt. Limited was first incepted with the production of phthalate plasticizers. Soon, the company has developed substantial competencies in the areas of biocides, pharmaceuticals and performance chemicals. Today, the company’s range of products includes Chlorophenol derivatives, Diclofenac Sodium & Miconazole Nitrate & their intermediates.

Pfizer CentreOne® is a completely distinct global contract development and manufacturing organization (CDMO), as well as a prominent provider of specialty APIs and intermediates. Supported by resources from Pfizer, we have provided technical knowledge, regulatory assistance, and long-term supply for more than 40 years. With a network of over 35 sites spanning six continents, we are capable of securely and effectively guiding complex compounds from development to commercial manufacture. For more details, please visit http://www.pfizercentreone.com

FAREVA stands as a prominent global pharmaceutical CDMO with leading expertise in the development and production of a wide variety of Drug Products and Active Pharmaceutical Ingredients (APIs). The company has a workforce of 13,000 individuals spread across 41 manufacturing facilities situated in 13 countries across EMEA and the Americas. Among these facilities, 18 are exclusively dedicated to pharmaceutical operations. FAREVA’s API division carries out its activities in 3 European locations situated in France and Germany.

Pfanstiehl is globally recognized as a leader in manufacturing cGMP high-purity, low-endotoxin, low-metal injectable-grade excipients and biopharmaceutical components for various applications in bioprocessing, formulation, and specialty areas. Additionally, Pfanstiehl operates as a prominent contract development and manufacturing organization (CDMO), specializing in the isolation, purification, custom synthesis, and scale-up development of small molecule Active Pharmaceutical Ingredients (APIs) ranging from gram to multi-ton commercial quantities. While many ingredient manufacturers or resellers cater to various industries like food, cosmetics, agriculture, and nutritional supplements, providing only a limited range of “pharma-grade” ingredients, Pfanstiehl’s exclusive focus lies in Biopharma applications, demonstrating a dedicated commitment to this specific sector

Mac-Chem has a National and Global footprint with a wide presence across the globe. Mac-Chem has carved a niche for itself in the exceedingly competitive and quality conscious sphere of Active Pharmaceutical Ingredients (API) manufacturing with US-FDA, EDQM, COFEPRIS, ANVISA, MFDS-Korea, WHO-GMP and ISO certified facilities

Haorui, established in the year 1997, operates as a manufacturer and provider of APIs, pharmaceutical intermediates, veterinary products, and food additives. Furthermore, it aids international pharmaceutical firms in achieving domestic registration for their finished dosage forms to support their global expansion efforts. The company's array of USFDA approved products includes Flumazenil, Granisetron HCl, Granisetron Base, Docetaxel Anhydrous, Irinotecan HCl, and Dasatinib Monohydrate among others. Its headquarters is situated in Shenzhen, China, while it maintains four manufacturing sites in Hubei, Zhejiang, Jiangxi, and Henan. The Hubei facility is recognized for its USFDA and EU GMP approvals, specializing in the production of high potency and oncology materials within a dedicated oncology workshop, meeting OEB 5 material production standards. Haorui prides itself as a dependable partner for all your pharmaceutical needs.

Biesterfeld Spezialchemie stands as a prominent global distributor of specialty chemical products, pharmaceuticals, and food ingredients. The organization provides comprehensive industry expertise and custom, application-oriented technical guidance across a varied product range focusing on the needs of specific sectors, such as composites and tooling, personal care and hygiene, healthcare, paints and coatings, adhesives, polyurethane, construction, nutrition, nutraceuticals, and electrical, electronic, and energy.

Sichuan Xieli Pharmaceutical Co., Ltd. was founded in 1980 with the development concept of "Xieli Tongchuang Health Cause". It mainly engages in the cultivation of ecological medicinal materials, the extraction of natural active ingredients from animals and plants, and the synthesis and research of their derivatives. It is based on the production of high value-added export products. There are mainly dozens of varieties, including rutin based cardiovascular and cerebrovascular drugs, plant flavonoids based capillary drugs, plant derived anti-tumor drugs, animal and plant extracts, and pharmaceutical intermediates.

Hubei Haosun Pharmaceutical Co.,Ltd. produces and sells drugs. The Company manufactures and sells irinotecan hydrochloride, docetaxel anhydrous, dasatinib monohydrate, flumazenil, and other products. Hubei Haosun Pharmaceutical markets its products primarily throughout China with limited overseas

Porton Advanced Solutions (Porton Advanced) operates as a Cell and Gene Therapy (CGT) CDMO. Our services encompass the entire process development (PD), analytical development (AD), GMP manufacturing, and testing services, catering to the therapeutic product requirements of clients at pre-clinical, clinical, and commercial stages. Our specialized teams for process and analytical development have established durable platform-based USP/DSP and GMP manufacturing capacity, along with exclusive technologies to enhance the success of our clients.

The Saraf group of enterprises was established by the forward-thinking Shri Mahavir G. Saraf in 1952. Sarex Overseas represents a segment of the Saraf group of corporations, and its primary operations center on being a prominent producer of Fine Chemicals and API Intermediates within India. The corporate headquarters of Sarex Overseas is situated in Mumbai, while its manufacturing facility is located in MIDC, Tarapur, which is approximately 100 kilometers from Mumbai in India. Sarex, which was founded in 2002, has garnered a reputation as a reputable Exporter, Manufacturer, and Supplier in India, focusing on producing Active Pharmaceutical Ingredients (API), Bulk Drug Intermediates, and Veterinary Medicines, including IVERMECTIN EP, among others. The organization's adept team of professionals, under expert guidance, processes all products, and the finished range undergoes thorough scrutiny by quality analysts based on various parameters such as composition, pH value, viscosity, and packaging. The company utilizes top-notch materials for packaging. Sarex specializes in the production of high-quality organic fine chemicals for the pharmaceutical and electronics industries, with a focus on Fridel craft, halogenation, nitration, oxidation, and high-pressure reactions. Notably, Sarex excels in process development and customer synthesis, operates pilot plants, and engages in bulk production of heterocycles like Tetrazoles, Triazines, and Quinazolines, among others. Its multipurpose plants include Glass-lined reactors, Stainless steel reactors, high-pressure reactors, and high vacuum distillation units, all supported by QA, QC, and R&D. The company serves as a supplier to numerous catalogue companies for small and bulk quantities and also provides toll manufacturing for large multinational companies.